|
KMID : 0191120140290081178
|
|
Journal of Korean Medical Science
2014 Volume.29 No. 8 p.1178 ~ p.1181
|
|
|
Susceptibility of Escherichia coli from Community-Acquired Urinary Tract Infection to Fosfomycin, Nitrofurantoin, and Temocillin in Korea
|
|
Seo Mi-Ran
Kim Seong-Jong
Kim Yeon-Jae
Kim Ji-Eun
Choi Tae-Yeal
Kang Jung-Oak
Wie Seong-Heon
Ki Mo-Ran
Cho Young-Kyun
Lim Seung-Kwan
Lee Jin-Seo
Kwon Ki-Tae
Lee Hyuck
Cheong Hee-Jin
Park Dae-Won
Ryu Seong-Yeol
Chung Moon-Hyun
Pai Hyun-Joo
|
|
|
Abstract
|
|
|
|
With increase of multi-drug resistant Escherichia coli in community-acquired urinary tract infections (CA-UTI), other treatment option with a therapeutic efficacy and a low antibiotic selective pressure is necessary. In this study, we evaluated in vitro susceptibility of E. coli isolates from CA-UTI to fosfomycin (FM), nitrofurantoin (NI), temocillin (TMO) as well as trimethoprim-sulfamethoxazole (SMX), ciprofloxacin (CIP) and cefepime (FEP). The minimal inhibitory concentrations were determined by E-test or agar dilution method according to the Clinical and Laboratory Standards Institute guidelines, using 346 E. coli collected in 12 Korean hospitals from March 2010 to February 2011. FM, NI and TMO showed an excellent susceptibility profile; FM 100% (346/346), TMO 96.8% (335/346), and NI 99.4% (344/346). Conversely, resistance rates of CIP and SMX were 22% (76/346) and 29.2% (101/349), respectively. FEP still retained an activity of 98.5%. In Korea, NI and TMO in addition to FM are a good therapeutic option for uncomplicated CA-UTI, especially for lower UTI.
|
|
|
KEYWORD
|
|
|
Community-Acquired Infections, Urinary Tract, Escherichia coli, Fosfomycin, Nitrofurantoin, Temocillin, Trimethoprim-Sulfamethoxazole combination, Ciprofloxacin, Cefepime, Minimal Inhibitory Concentration
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
    
|
|